Package: Mediana 1.0.9

Mediana: Clinical Trial Simulations

Provides a general framework for clinical trial simulations based on the Clinical Scenario Evaluation (CSE) approach. The package supports a broad class of data models (including clinical trials with continuous, binary, survival-type and count-type endpoints as well as multivariate outcomes that are based on combinations of different endpoints), analysis strategies and commonly used evaluation criteria.

Authors:Gautier Paux, Alex Dmitrienko.

Mediana_1.0.9.tar.gz
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manual.pdf |manual.html
DESCRIPTION |NEWS
card.svg |card.png
Mediana/json (API)

# Install 'Mediana' in R:
install.packages('Mediana', repos = c('https://gpaux.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/gpaux/mediana/issues

On CRAN:

Conda:

biostatisticsclinical-trial-simulationsclinical-trialssimulations

6.67 score 32 stars 49 scripts 394 downloads 2 mentions 35 exports 12 dependencies

Last updated from:e3a7d7f492. Checks:9 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-devel-x86_64OK140
source / vignettesOK197
linux-release-x86_64OK137
macos-release-arm64OK146
macos-oldrel-arm64OK175
windows-develOK86
windows-releaseOK95
windows-oldrelOK78
wasm-releaseOK142

Exports:AdjustCIsAdjustPvaluesAnalysisModelAnalysisStackCriterionCSECustomLabelDataModelDataStackDesignEvaluationModelEventExtractAnalysisStackExtractDataStackfamiliesGenerateDataGenerateReportMultAdjMultAdjProcMultAdjStrategyOutcomeDistparametersPresentationModelProjectSamplesamplesSampleSizeSectionSimParametersStatisticstatisticsSubsectionTableTesttests

Dependencies:codetoolsdigestdoParalleldoRNGforeachiteratorslatticeMASSMatrixmvtnormrngtoolssurvival

Case studies
Introduction | Case study 1 | Case study 2 | Case study 3 | Case study 4 | Case study 5 | Case study 6 | Normally distributed endpoint | Define a Data Model | Define an Analysis Model | Define an Evaluation Model | Perform Clinical Scenario Evaluation | Summarize the Simulation Results | Summary of simulation results in R console | General a Simulation Report | Presentation Model | Report generation | Download | Binary endpoint | Survival-type endpoint | Survival-type endpoint (with censoring) | Count-type endpoint | Summary | Generate a Simulation Report | Create a Customized Simulation Report | Define a Presentation Model | Report without subsections | Report with subsections | Report with combined sections

Last update: 2019-03-06
Started: 2017-04-25

Adjusted p-values and one-sided simultaneous confidence limits
Introduction | AdjustPvalues function | Description | Inputs | Outputs | Example | Traditional nonparametric and semiparametric procedures | Traditional parametric procedures | Gatekeeping procedures | AdjustCIs function

Last update: 2019-01-14
Started: 2017-08-09

Mediana: an R package for clinical trial simulations
Introduction | About | Expert and development teams | Installation | Latest release | Development version | Clinical Scenario Evaluation Framework | Case studies | Data model | Initialization | Components of a data model | OutcomeDist object | Description | Example | Sample object | SampleSize object | Event object | Design object | Analysis model | Components of an analysis model | Test object | Statistic object | MultAdjProc object | MultAdjStrategy object | MultAdj object | Evaluation model | Components of an evaluation model | Criterion object | Examples | Clinical Scenario Evaluation | Clinical Scenario Evaluation objects | SimParameters object | CSE function | Summary of results | Simulation report | Specific objects | Project object | Section object | Subsection object | Table object | CustomLabel object | GenerateReport function

Last update: 2019-01-14
Started: 2017-04-25